GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs947211 | 1 | rs1775151 | chr1:205745684 | RAB7L1 | chr1:205737115-205744610:- | 0.27 | 4 | 7.56E-5 | Parkinson's disease |
| BLCA | cis | rs9475752 | 1 | rs17752459 | chr6:56798755 | BEND6 | chr6:56819773-56892138:+ | -0.29 | -4.02 | 7.02E-5 | Menarche (age at onset) |
| BLCA | cis | rs17761864 | 1 | rs17761723 | chr17:2107090 | SRR | chr17:2207248-2228553:+ | 0.37 | 6.36 | 5.75E-10 | Esophageal cancer (squamous cell) |
| BLCA | cis | rs17761864 | 1 | rs17761864 | chr17:2171637 | SRR | chr17:2207248-2228553:+ | -0.39 | -6.81 | 3.86E-11 | Esophageal cancer (squamous cell) |
| BLCA | cis | rs853679 | 1 | rs1778508 | chr6:28229881 | ZNF389 | chr6:28129551-28137375:+ | 0.35 | 4.5 | 9.14E-6 | Depression |
| BLCA | cis | rs853679 | 1 | rs1778511 | chr6:28229411 | ZNF389 | chr6:28129551-28137375:+ | 0.34 | 4.3 | 2.13E-5 | Depression |
| BLCA | cis | rs7714584 | 1 | rs17800886 | chr5:150309539 | LOC134466 | chr5:150310000-150326146:- | 0.53 | 6.69 | 8.09E-11 | Crohn's disease |
| BLCA | cis | rs7714584 | 1 | rs17800987 | chr5:150323428 | LOC134466 | chr5:150310000-150326146:- | 0.54 | 6.8 | 4.03E-11 | Crohn's disease |
| BLCA | cis | rs17818399 | 1 | rs17818399 | chr2:46826026 | ATP6V1E2 | chr2:46738988-46769696:- | -0.26 | -4.27 | 2.42E-5 | Height |
| BLCA | cis | rs4409766 | 1 | rs17878846 | chr10:104630412 | AS3MT | chr10:104613967-104661653:+ | -0.34 | -3.95 | 9.24E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BLCA | cis | rs4409766 | 1 | rs17878846 | chr10:104630412 | SFXN2 | chr10:104474298-104498946:+ | -0.35 | -3.94 | 9.88E-5 | Hypertension;Systolic blood pressure;Diastolic blood pressure |
| BLCA | cis | rs9457247 | 1 | rs1794693 | chr6:167405670 | RNASET2 | chr6:167343008-167412795:- | -0.25 | -5.15 | 4.08E-7 | Crohn's disease |
| BLCA | cis | rs2243480 | 1 | rs1796220 | chr7:66062100 | CCT6P1 | chr7:65216092-65228661:+ | 0.35 | 4.82 | 2.04E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs1796228 | chr7:66033084 | CCT6P1 | chr7:65216092-65228661:+ | 0.37 | 4.89 | 1.48E-6 | Diabetic kidney disease |
| BLCA | cis | rs1800615 | 1 | rs1800615 | chr1:15832281 | CASP9 | chr1:15817324-15851384:- | 0.24 | 4.55 | 7.28E-6 | Glomerular filtration rate (creatinine) |